Thermo Fisher Scientific VGLL2 Polyclonal Antibody
VGLL2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 웨스턴 블롯(WB)에 적합합니다. 토끼 IgG 기반으로 제작되었으며, 비결합형 액상 형태입니다. 근육 분화 관련 연구 및 VGLL2 발현 분석에 활용됩니다.
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Thermo Fisher Scientific VGLL2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (57 SQTPASIKEEEGSPEKER 74) of VGLL2/VITO1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2540891 |
Target Information
VGLL2 is the master regulator in wing development in Drosophila, acting through a complex by interacting with scalloped, a homolog of vertebrate TEF proteins. Northern and dot blot analyses of human adult tissues detected VGLL2 expression in skeletal muscle. In situ hybridization revealed VGLL2 expression in differentiating somites and branchial arches during mouse embryogenesis.
VITO1 is the clone of VGLL2 and contains a scalloped interaction domain (SID). VITO1 is more highly expressed in differentiated myotubes from the mouse C2C12 myogenic cell line than in undifferentiated cells. During differentiation in mouse C2C12 cells, VGLL2 mRNA levels increase and VGLL2 protein translocates from the cytoplasm to the nucleus. Interference with VITO1 expression by small interfering RNA attenuated differentiation in C2C12 muscle cells. Therefore, this protein is an important component of the myogenic program.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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