Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
NOTCH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ChIP-Seq에 사용 가능. 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피로 정제된 액상 항체. 연구용으로만 사용.
- 카탈로그번호
- PA527458
- 판매단위
- pk
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Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| ChIP-sequencing (ChIP-Seq) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1669–1855 of Human NOTCH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544934 |
Product Specific Information
- Recommended positive controls: A431, HeLa, HepG2
- Predicted reactivity: Mouse (95%), Rat (89%), Rhesus Monkey (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type I transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, distinct domain types.
NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity and cholestasis, along with cardiac, skeletal, and ophthalmologic manifestations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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