Thermo Fisher Scientific CD71 (Transferrin Receptor) Polyclonal Antibody
Rabbit polyclonal antibody against human CD71 (Transferrin Receptor). Validated for IHC (paraffin) at 1:1,000 dilution. Protein A purified, 1 mg/mL in PBS with BSA and glycerol. Suitable for research use in iron metabolism and erythropoiesis studies.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human CD71 (aa 463–750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802737 |
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and concomitant loss of affinity of apotransferrin for its receptor.
The transferrin receptor is essential for the development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse by athletes and as a diagnostic marker for various anemias, including those associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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