Thermo Fisher Scientific SF3a120/SAP114 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• Based on 100% sequence identity, predicted to react with Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Northern white‑cheeked gibbon, Small‑eared galago, and Ferret.

Target Information

This gene encodes subunit 1 of the splicing factor 3a (SF3A) protein complex. The heterotrimeric SF3A complex (subunits 1, 2, 3) is required for converting 15S U2 snRNP into the active 17S particle that performs pre‑mRNA splicing.
Subunit 1 belongs to the SURP protein family, containing tandemly repeated SURP motifs in the N‑terminal region and a proline‑rich plus ubiquitin‑like domain in the C‑terminal region. The SURP motifs mediate RNA binding and are essential for binding to subunit 3, while interactions with subunit 2 occur through sequences C‑terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.