Thermo Fisher Scientific GPR17, G Protein-Coupled Receptor 17 Polyclonal Antibody
GPR17 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of a part of carboxyl-terminal which is identical in human, mouse and rat GPR17. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600–1,000 members and is the largest known class of molecular targets with proven therapeutic value.
GPR17 is an orphan G protein-coupled receptor involved in orchestration of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes and signals through G(i) and inhibition of adenylyl cyclase.
It may mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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