Thermo Fisher Scientific Phospho-GPR17 (Ser351, Thr356) Polyclonal Antibody
인간 GPR17 단백질의 Ser351/Thr356 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 1 mg/mL 농도, 연구용으로만 사용.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human GPR17 around the phosphorylation site Ser351/Thr356 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600–1,000 members and represents the largest known class of molecular targets with proven therapeutic value.
GPR17 is an orphan G protein-coupled receptor involved in orchestration of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes and signals through G(i) with inhibition of adenylyl cyclase.
May mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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