Thermo Fisher Scientific Acetyl-p53 (Lys373) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Acetyl-p53 only when acetylated at Lys373.

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest.
It contains several domains: an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is important for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation.
p53 plays a key role in preventing proliferation of damaged cells and acts as an anticancer factor. It is also linked to aging, oxidative stress, and learning/memory processes. Mutations in the TP53 gene are common in many human cancers and can lead to loss of tumor suppressor activity. Germline mutations are associated with cancer-prone syndromes such as Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.