Thermo Fisher Scientific c-Maf Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine

Target Information

c-Maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.

c-Maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, where it exerts transcriptional regulation through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberrations involving maf are found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.