Thermo Fisher Scientific c-Maf Polyclonal Antibody
c-Maf 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 최적화되어 있습니다. 비결합(Unconjugated) 형태의 액상 제품이며, 4°C에서 보관합니다. c-Maf 관련 전사 조절 연구 및 세포 분화 연구에 활용 가능합니다.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog (c-Maf) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine
Target Information
c-Maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.
c-Maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, where it exerts transcriptional regulation through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberrations involving maf are found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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