Thermo Fisher Scientific GC Vitamin D Binding Protein Monoclonal Antibody (VDBP/4482)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Immunoelectrophoresis (IE)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human liver, kidney, or pancreas
• Cellular Localization: Secreted

Specificity Comments:
Vitamin D-binding protein (DBP) is a multifunctional serum protein that binds to plasma membranes of numerous cell types and mediates diverse cellular functions. The DBP gene (also known as GC) is located on human chromosome 4q13.3.
DBP functions in organ-specific transportation of vitamin D and its metabolites within the endocrine system. It also exhibits immunomodulatory properties, binding to leukocyte surfaces and acting as a co-chemotactic factor for C5a.
Additionally, DBP binds globular actin with high affinity, contributing to actin clearance from the bloodstream and playing a role in osteoclast differentiation. These diverse functions depend on its cell surface binding capability.

Target Information

GC (Vitamin D-binding protein) is involved in:

• Vitamin D transport and storage
• Scavenging of extracellular G-actin
• Enhancement of C5α chemotactic activity for neutrophils during inflammation
• Macrophage activation

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.