Thermo Fisher Scientific GC Vitamin D Binding Protein Monoclonal Antibody (VDBP/4482)
인간 GC 단백질을 인식하는 단클론 항체로, 비타민 D 결합 단백질 연구에 적합. IHC, 면역전기영동, 펩타이드 어레이 등 다양한 응용 가능. 비접합 액상 형태로 200 µg/mL 농도, 4°C에서 안정적 저장. 단백질 A/G 정제 및 24개월 안정성 보장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Immunoelectrophoresis (IE)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VDBP/4482 |
| Immunogen | Recombinant fragment (around aa 35–175) of human GC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human liver, kidney, or pancreas
- Cellular Localization: Secreted
Specificity Comments:
Vitamin D-binding protein (DBP) is a multifunctional serum protein that binds to plasma membranes of numerous cell types and mediates diverse cellular functions. The DBP gene (also known as GC) is located on human chromosome 4q13.3.
DBP functions in organ-specific transportation of vitamin D and its metabolites within the endocrine system. It also exhibits immunomodulatory properties, binding to leukocyte surfaces and acting as a co-chemotactic factor for C5a.
Additionally, DBP binds globular actin with high affinity, contributing to actin clearance from the bloodstream and playing a role in osteoclast differentiation. These diverse functions depend on its cell surface binding capability.
Target Information
GC (Vitamin D-binding protein) is involved in:
- Vitamin D transport and storage
- Scavenging of extracellular G-actin
- Enhancement of C5α chemotactic activity for neutrophils during inflammation
- Macrophage activation
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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