Thermo Fisher Scientific Phospho-KChIP3 (Ser63) Polyclonal Antibody
Phospho-KChIP3 (Ser63) 폴리클로날 항체로, 인간 및 마우스 시료에 반응합니다. Western blot, IHC, ICC, ELISA에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관하며 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:20,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human DREAM around the phosphorylation site of S63 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576404 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system. In cardiac tissue, Kv4 channels participate in the repolarization phase of the action potential, while in the brain, they prevent reverse propagation of action potentials.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels to regulate their function. There are three known KChIPs:
- KChIP1: expressed in the brain
- KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
- KChIP3: also known as calsenilin or DREAM, expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also acts as a transcriptional regulator by binding to the regulatory DRE and repressing transcription of early-response genes such as c-fos. It is also associated with presenilins and implicated in beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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