Thermo Fisher Scientific SAP102 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
HLNDMYAPPDY ASTFTALADN HISHNSSLGY LGAVESKVSY PAPPQVPPTR YSPIPRHMLA EEDFTREPRK IILHK

Highest antigen sequence identity to the following orthologs: mouse 99%, rat 99%.

Target Information

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain.
It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering, contributing to neuronal plasticity. SAP102 is believed to participate in the clustering of proteins such as NMDA receptors and shaker-type potassium channels at the synaptic membrane in CNS neurons.
NMDA receptors and Shaker-type potassium channels share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins sharing this motif (β1 adrenergic receptor, some serotonin receptors, sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 via PDZ domains.
Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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