Thermo Fisher Scientific Angiogenin Recombinant Rabbit Monoclonal Antibody (HL2215)
Recombinant rabbit monoclonal antibody (clone HL2215) targeting Angiogenin. Validated for WB, IHC(P), and ICC/IF. Reacts with human and rat samples. High purity (Protein A) and unconjugated form, ideal for angiogenesis and neurodegenerative disease res...
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2215 |
| Immunogen | Recombinant fragment of human Angiogenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092426 |
Target Information
Angiogenin (ANG or ANG I) plays a key role in neovascularization and blood vessel formation. It is structurally similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease, inhibiting protein synthesis by hydrolyzing cellular tRNAs. ANG interacts with endothelial cell-surface actin, influencing cytoskeletal dynamics. It is implicated in solid tumor development, and its antagonists can inhibit tumor growth. Mutations in ANG are linked to amyotrophic lateral sclerosis type 9 (ALS9), connecting ANG to both ALS and Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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