Thermo Fisher Scientific GeneBLAzer CRHR2-CRE-bla CHO-K1 Cells
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| K1733 | - | Thermo Fisher Scientific K1733 GeneBLAzer CRHR2-CRE-bla CHO-K1 Cells Each pk | 재고문의 | pk | 0원 | - | 0원 | |
다른 상품 둘러보기
Thermo Scientific™
GeneBLAzer™ CRHR2-CRE-bla CHO-K1 Cells
GeneBLAzer™ CRHR2-CRE-bla CHO-K1 cells contain the human Corticotropin Releasing Factor Receptor 2 (CRHR2) stably integrated into the CellSensor™ CRE-bla CHO-K1자세히 알아보기
GeneBLAzer™ CRHR2-CRE-bla CHO-K1 cells contain the human Corticotropin Releasing Factor Receptor 2 (CRHR2) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. No. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer™ CRHR2-CRE-bla CHO-K1 cells are functionally validated for Z` and EC50 concentrations of CRF. In addition, GeneBLAzer™ CRHR2-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
Corticotropin releasing factor is a 41-amino acid peptide that plays a role in the integration of autonomic, neuroendocrine, and behavioral responses to stress. These effects are mediated through two receptor families, CRHR1 and CRHR2. While CRF was originally isolated from the hypothalamus, where it was shown to be the primary neuroregulator mediating the hypothalamic-pituitary-adrenocortical stress axis, it has since been found to be widely distributed outside the hypothalamus throughout the central nervous system. Presently, there are five distinct targets for CRF with unique pharmacology and localization. These have been placed into three distinct classes, two of which are the G-protein-coupled receptors CRF1 (CRHR1) and CRF2 (CRHR2). Three functional splice variants have been identified for the mammalian CRHR2 receptor, although pharmacological characterization of these splice variants revealed no major differences between them.
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사양
등록 번호NM_001883.2
어세이 입력Cell-based beta lactamase reporter gene
셀 상태Dividing Cells
검출 방법Fluorescence
용도(애플리케이션)FRET
유전자 기호CRHR2
개체군 상태Single Cell Clone Origin
제품라인GeneBLAzer™
수량2 x 106 Cells
리포터 유전자BLA (Beta-Lactamase)
타겟 입력CRHR2
세포주CHO-K1
System TypeGeneBLAzer™
Druggable TargetGPCR
Unit SizeEach
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