Thermo Fisher Scientific FGR Monoclonal Antibody (3F2)
Human FGR 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로, WB, IHC, ELISA 등 다양한 분석에 적합. 고순도 Affinity chromatography 정제, PBS buffer에 보존. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F2 |
| Immunogen | FGR (AAH64382, 1–90 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. It signals within multiple pathways, including the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains that mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. It localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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