Thermo Fisher Scientific Human IL-1 alpha, Animal-Free Recombinant Protein, PeproTech
인체 유래 IL-1α 재조합 단백질로, 동물 유래 성분 없이 생산된 고순도(≥98%) 시약입니다. E. coli 발현 시스템에서 제조되며, 마우스 D10S 세포 증식을 유도하는 생물학적 활성을 가집니다. 염증 및 면역 반응 연구에 적합합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (5 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino acid sequence | SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA |
| Molecular weight | 18 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% (SDS-PAGE, HPLC) |
| Endotoxin concentration | < 0.1 EU/µg |
| Activity | Stimulates proliferation of mouse D10S cells. ED50 ≤ 0.001 ng/ml (≥ 1 × 10⁹ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IL-1α (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene located on chromosome 2q13 and signals through IL-1RI and IL-1RII receptors, shared with IL-1β.
IL-1α plays a key role in innate immunity by inducing other proinflammatory cytokines and initiating acute-phase responses. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding competitively.
This cytokine influences NF-κB and MAPK signaling pathways, promotes IL6 and COX-2 expression, and enhances nitric oxide production. Elevated IL-1α levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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