Thermo Fisher Scientific Human/Mouse/Rat Activin A, Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 재조합 Activin A 단백질로 인간, 생쥐, 랫드에서 모두 적용 가능. 세포 증식 억제 활성 검증 완료. 고순도(≥97%) 및 저엔도톡신(<0.1 EU/µg) 수준. 연구용으로만 사용 가능.
- 카탈로그번호
- AF-120-14E-xxxxx (3개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human/Mouse/Rat Activin A, Animal-Free Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Tested in vitro
- View 30 publications
Miscellaneous PubMed (Misc)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS |
| Molecular Weight | 26 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥97% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Inhibits proliferation of mouse MPC-11 cells; ED50 ≤ 2.0 ng/ml, specific activity ≥ 5 × 10^5 units/mg |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- Catalog No. AF-120-14E-1MG is supplied as 2 × 500 µg (AF-120-14E-500UG).
- Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues.
- Shipped at ambient temperature.
- For storage, handling, and reconstitution details, refer to the lot-specific Certificate of Analysis.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily.
They signal through heteromeric complexes of receptor serine kinases, including at least two type I (I, IB) and two type II (II, IIB) receptors.
These transmembrane receptors consist of:
- Ligand-binding extracellular domain with cysteine-rich region
- Transmembrane domain
- Cytoplasmic domain with serine/threonine kinase specificity
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression.
Upon ligand binding, type I and II receptors form a stable complex, allowing phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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