Thermo Fisher Scientific UHRF1/2 Polyclonal Antibody
UHRF1/2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB, IHC, ICC, Flow, ELISA 등 다양한 어플리케이션에 사용 가능. 단백질 A로 정제된 고순도 액상 항체로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human UHRF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
Tissue specificity: Expressed in thymus, bone marrow, testis, lung, and heart. Overexpressed in breast cancer.
UHRF2 is an E3 ubiquitin-protein ligase that acts as an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, it may contribute to tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins CCND1 and CCNE1 in a phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Functions as an E3 SUMO- but not ubiquitin-protein ligase for ZNF131.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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