Thermo Fisher Scientific PPOX Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total PPOX protein.

Target Information

Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. The PPOX protein localizes to the inner mitochondrial membrane across various tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX leads to variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and/or neurological manifestations. The rare homozygous variant of variegate porphyria results in severe PPOX deficiency, causing early-onset photosensitization, skeletal abnormalities of the hand, short stature, mental retardation, and convulsions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.