Thermo Fisher Scientific PPOX Polyclonal Antibody
Thermo Fisher Scientific의 PPOX Polyclonal Antibody는 인간 및 생쥐 시료에서 PPOX 단백질을 검출하는 고품질 항체입니다. Western blot과 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human protoporphyrinogen oxidase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636185 |
Product Specific Information
This antibody detects endogenous levels of total PPOX protein.
Target Information
Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. The PPOX protein localizes to the inner mitochondrial membrane across various tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX leads to variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and/or neurological manifestations. The rare homozygous variant of variegate porphyria results in severe PPOX deficiency, causing early-onset photosensitization, skeletal abnormalities of the hand, short stature, mental retardation, and convulsions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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