Thermo Fisher Scientific CD11b Polyclonal Antibody
CD11b 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western Blot, IHC, Flow Cytometry 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. Lyophilized 형태로 제공되며 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | View publication |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human CD11b recombinant protein (Position: F17–T382) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746648 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18).
The CD11b/CD18 heterodimeric complex, known as integrin alpha-M beta-2, Mac-1, or CR3 (complement receptor 3), is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- A subset of NK cells
- A subset of dendritic cells
- Microglia in the brain
CD11b/CD18 acts as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
These interactions are essential for cell-cell and cell-matrix adhesion.
Expression details:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
- Commonly used as a microglial marker in nervous tissue
CD11b expression increases during monocyte maturation and varies among macrophage types.
Peritoneal macrophages express higher levels of CD11b than splenic macrophages.
Dysfunction of CD11b is associated with systemic lupus erythematosus and ITGAM-related susceptibility to lupus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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