Thermo Fisher Scientific CRY1 Monoclonal Antibody (OTI6C6), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/post-translation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear homology to blue-light receptors and photolyases.

In Drosophila, CRY acts as a photoreceptor for the circadian clock, binding to the clock component TIM in a light-dependent manner to block its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as PER1, PER2, and TIM. They act as light-independent components of the circadian clock, regulating Per1 transcriptional cycling through interactions with both activators and feedback inhibitors.

Mutant mice lacking Cry1 or Cry2 display accelerated or delayed periodicity of locomotor activity, respectively. The combination of both proteins is essential for synchronization to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice exhibit instantaneous arrhythmicity, indicating loss of internal circadian rhythm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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