Thermo Fisher Scientific TAF4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TAF4.

Target Information

TAF II p105 (also called TAF4B) is a cell type–specific transcriptional co-activator and a component of the TFIID complex. It is expressed primarily in B cells and ovarian granulosa cells, where it interacts with OCBA/POU2AF1 to activate B cell–specific octamer-dependent transcription.
TAF II p105 also co-activates the transcription factor NFκB and is essential for activation of anti-apoptotic genes such as TNFAIP3.
TAF II p135 (also known as TAF4, TAF2C, TAF2C1, TAF4A, or TAFII130) is a 1,085 amino acid subunit of TFIID that enhances transcriptional activation triggered by thyroid hormone (TR) or retinoic acid (RA). Localized to the nucleus, TAF II p135 contains one TAFH domain and binds proteins with glutamine-rich domains, such as the transcription factor CREB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.