Thermo Fisher Scientific IL-10 Monoclonal Antibody (CC320)
IL-10 단클론 항체(CC320)는 Bovine, Horse, Goat, Sheep 반응성을 가지며, Flow Cytometry, ELISA, Functional Assay에 사용됩니다. 저엔도톡신, 무보존제 제형으로 연구용에 적합하며, IL-10 관련 면역조절 연구에 활용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA (ELISA)
- Tested Dilution: 5–10 µg/mL
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Horse, Goat, Sheep |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC320 |
| Immunogen | Plasmid cDNA encoding bovine IL-10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538117 |
Product Specific Information
- Membrane permeabilization is required for flow cytometry applications.
- This product is a low-endotoxin, preservative-free formulation.
- Endotoxin level: <0.01 EU/µg.
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and some lymphocytes. It regulates immune responses and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages.
IL-10 enhances B cell survival, proliferation, and antibody production, blocks NF-kappa B activity, and regulates the JAK-STAT signaling pathway.
Knockout studies in mice indicate IL-10 is essential for intestinal immune regulation. Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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