Thermo Fisher Scientific CD48 Monoclonal Antibody (MEM-102), FITC

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (Cat# MA1-19119)
• APC (Cat# MA1-10240)
• Biotin (Cat# MA1-19500)
• PE (Cat# MA1-10241)
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with CD48 (Blast-1), a 40–47 kDa GPI-anchored extracellular membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells. It is negative on granulocytes, platelets, and erythrocytes.

Target Information

CD48 (Blast-1) belongs to the CD2 subset of the immunoglobulin superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244, and others. These molecules mediate homotypic or heterotypic adhesion among hematopoietic cells.
CD48 serves as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2. The 2B4–CD48 interaction among NK and NK-T cells regulates cell proliferation and activation. CD48 expression increases in several infectious diseases and allergic airway conditions, making it a potential pharmacological target for diseases such as allergic rhinitis and asthma.
It is strongly expressed on lymphocytes and monocytes, weakly on granulocytes, and absent on platelets, fibroblasts, epithelium, and endothelium. CD48 is also a marker for detecting defects in GPI anchoring structure in patients with paroxysmal nocturnal hemoglobinuria (PNH).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지