Thermo Fisher Scientific ATG16L1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAQLRIKHQE ELTELHKKRG ELAQLVIDLN NQMQRKDREM QMNEAKIAEC LQTISDLETE CLDLRTKLCD LERANQTLKD EYDALQITFT ALEGKLRKTT EENQELVTRW MAEKAQEANR LNAENEKDSR RRQARLQKEL AEAAKEPLPV EQDDDIEVIV DETSDHTEET SPVRAISRAA TKRLSQPAGG LLDSITNIFG RRSVSSFPVP QDNVDTHPGS GKEVRVPATA LCVFDAHDGE VNAVQFSPGS RLLATGGMDR RVKLWEVFGE KCEFKGSLSG SNAGITSIEF DSAGSYLLAA SNDFASRIWT VDDYRLRHTL TGHSGKVLSA KFLLDNARIV SGSHDRTLKL WDLRSKVCIK TVFAGSSCND IVCTEQCVMS GHFDKKIRFW DIRSESIVRE MELLGKITAL DLNPERTELL SCSRDDLLKV IDLRTNAIKQ TFSAPGFKCG SDWTRVVFSP DGSYVAAGSA EGSLYIWSVL TGKVEKVLSK QHSSSINAVA WSPSGSHVVS VDKGCKAVLW AQY

Target Information

Autophagy-related protein 16L (ATG16L) is encoded by the ATG16L gene located on chromosome 2 in humans.
Also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate and oligomerize with ATG16L to form the Atg16L complex (≈800 kDa), facilitating LC3 lipidation to phosphatidylethanolamine (PE) — a key marker for autophagy.
The ATG16L complex, along with other ATGs such as ATG18 and ATG21, prevents premature cleavage of ATG8-PE by cysteine protease Atg4 until autophagosome completion.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.