Thermo Fisher Scientific IFT57 Monoclonal Antibody (1G8)
Human IFT57 단백질을 표적으로 하는 Mouse IgG2a monoclonal antibody (Clone 1G8). Western blot 및 ELISA에 적합. PBS buffer에 보관되며 보존제가 없음. 연구용으로만 사용 가능.
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- H00055081-M02
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G8 |
| Immunogen | IFT57 (NP_060480, 214–312 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QTYHLDMNET AKQEDILEST TDAAEWSLEV ERVLPQLKVT IRTDNKDWRI HVDQMHQHRS GIESALKETK GFLDKLHNEI TRTLEKISSR EKYINNQLE
Target Information
HIPPI is required for the formation of cilia and plays an indirect role in sonic hedgehog signaling, as cilia are essential for hedgehog pathway activity. It has pro-apoptotic function via interaction with HIP1, leading to recruitment of caspase-8 (CASP8) and induction of apoptosis. HIPPI can bind the DNA sequence motif 5'-AAAGACATG-3' found in promoters of caspase genes (CASP1, CASP8, CASP10), suggesting potential transcriptional regulatory activity, though its relevance remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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