Thermo Fisher Scientific Sarcomeric alpha Actin Monoclonal Antibody (5C5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is specific to alpha-skeletal and alpha-cardiac muscle actins. It does not react with smooth muscle tissue.

Target Information

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved and play essential roles in cell motility, structure, and integrity.
Alpha, beta, and gamma actin isoforms have been identified:

• Alpha actins: major components of the contractile apparatus in muscle
• Beta and gamma actins: involved in the regulation of cell motility

This actin is an alpha actin found in skeletal muscle.
Mutations in this gene are associated with:

• Nemaline myopathy type 3
• Congenital myopathy with excess thin myofilaments
• Congenital myopathy with cores
• Congenital myopathy with fiber-type disproportion

These conditions lead to muscle fiber defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.