Thermo Fisher Scientific Sarcomeric alpha Actin Monoclonal Antibody (5C5)
사코메릭 알파 액틴을 특이적으로 인식하는 Mouse IgM 단일클론 항체. IHC(P) 및 ICC/IF에 적합하며, 알파-골격근 및 알파-심근 액틴 검출에 사용. 휴먼 및 래빗 반응성. 4°C에서 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rabbit |
| Published Species | Dog, Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C5 |
| Immunogen | Purified rabbit striated muscle actin (Sarcomeric alpha Actin, UniProt ID: P68135-1, antigen range: 1–377) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_795757 |
Product Specific Information
This antibody is specific to alpha-skeletal and alpha-cardiac muscle actins. It does not react with smooth muscle tissue.
Target Information
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved and play essential roles in cell motility, structure, and integrity.
Alpha, beta, and gamma actin isoforms have been identified:
- Alpha actins: major components of the contractile apparatus in muscle
- Beta and gamma actins: involved in the regulation of cell motility
This actin is an alpha actin found in skeletal muscle.
Mutations in this gene are associated with:
- Nemaline myopathy type 3
- Congenital myopathy with excess thin myofilaments
- Congenital myopathy with cores
- Congenital myopathy with fiber-type disproportion
These conditions lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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