Thermo Fisher Scientific PDGFRB Monoclonal Antibody (OTI1D2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. It acts as a mitogen for cells of mesenchymal origin. The receptor can form either homodimers or heterodimers with PDGFRA, depending on the ligand.
The PDGFRB gene is located on chromosome 5, adjacent to genes for GM-CSF and M-CSF receptor, and may be involved in the 5q- syndrome.
A chromosomal translocation between chromosomes 5 and 12, fusing PDGFRB (CD140b) with ETV6, results in a chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.