Thermo Fisher Scientific FKBP5/FKBP51 Polyclonal Antibody
Rabbit polyclonal antibody targeting FKBP5/FKBP51, validated for WB, IHC, and IP applications. Recognizes human FKBP5 region 407–457. Supplied as liquid form, 0.20 mg/mL concentration, stored at 4°C. For research use only.
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Thermo Fisher Scientific FKBP5/FKBP51 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 407 and 457 of human FK506 binding protein 5 (51 kDa FK506-binding protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
FKBP5 is a member of the immunophilin protein family, which plays a role in immunoregulation and cellular processes involving protein folding and trafficking.
It acts as a cis-trans prolyl isomerase binding to the immunosuppressants FK506 and rapamycin, mediating calcineurin inhibition.
FKBP5 interacts with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein.
The FKBP5 gene contains multiple polyadenylation sites, and alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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