Thermo Fisher Scientific CYFIP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CYFIP1. Recombinant protein control fragment (Product #RP-103976). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYFIP1,uniProtId:Q7L576-1,ncbiNodeId:9606,antigenRange:160-218,antigenLength:1253,antigenImageFileName:PA5-64360_CYFIP1_Q7L576-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64360_CYFIP1_Q7L576-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640312

Product Specific Information

Immunogen sequence: TLGKFINMFA VLDELKNMKC SVKNDHSAYK RAAQFLRKMA DPQSIQESQN LSMFLANHN

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.