Thermo Fisher Scientific FNIP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FNIP1. Recombinant protein control fragment (Product #RP-104226). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FNIP1,uniProtId:Q8TF40-1,ncbiNodeId:9606,antigenRange:779-854,antigenLength:1166,antigenImageFileName:PA5-64359_FNIP1_Q8TF40-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64359_FNIP1_Q8TF40-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641706

Product Specific Information

Immunogen sequence: HHTKPLKEER GAIDQHQETK QTTKDQSGES DTQNMVSEEP CELPCWNHSD PESMSLFDEY FNDDSIETRT IDDVPF

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.

Target Information

FNIP1 encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. Diseases associated with FNIP1 include Birt-Hogg-Dube Syndrome and Pleural Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.