Thermo Fisher Scientific NELF Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 226-505 of human NSMF (NP_0011244431) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NELF,uniProtId:Q6X4W1-1,ncbiNodeId:9606,antigenRange:226-505,antigenLength:530,antigenImageFileName:PA5-92264_NELF_Q6X4W1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92264_NELF_Q6X4W1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.3 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806425

Product Specific Information

Immunogen sequence: FQTATTTMQA NFRKHLRMVG SRRVKAQTFA ERRERSFSRS WSDPTPMKAD TSHDSRDSSD LQSSHCTLDE AFEDLDWDTE KGLEAVACDT EGFVPPKVML ISSKVPKAEY IPTIIRRDDP SIIPILYDHE HATFEDILEE IERKLNVYHK GAKIWKMLIF CQGGPGHLYL LKNKVATFAK VEKEEDMIHF WKRLSRLMSK VNPEPNVIHI MGCYILGNPN GEKLFQNLRT LMTPYRVTFE SPLELSAQGK QMIETYFDFR LYRLWKSRQH SKLLDFDDVL; Positive Samples: LO2, HT-29, 293T, BT-474, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Nucleus envelope, Nucleus matrix, Nucleus membrane, Peripheral membrane protein, cell cortex, cytoskeleton, dendrite, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome

Target Information

NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.