Thermo Fisher Scientific T-bet Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 322-535 of human TBX21 (NP_0374831) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:T-bet,uniProtId:Q9UL17-1,ncbiNodeId:9606,antigenRange:322-535,antigenLength:535,antigenImageFileName:PA5-92277_T-bet_Q9UL17-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92277_T-bet_Q9UL17-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806428

Product Specific Information

Positive Samples: B cells; Cellular Location: Nucleus

Immunogen sequence: KGFRENFESM YTSVDTSIPS PPGPNCQFLG GDHYSPLLPN QYPVPSRFYP DLPGQAKDVV PQAYWLGAPR DHSYEAEFRA VSMKPAFLPS APGPTMSYYR GQEVLAPGAG WPVAPQYPPK MGPASWFRPM RTLPMEPGPG GSEGRGPEDQ GPPLVWTEIA PIRPESSDSG LGEGDSKRRR VSPYPSSGDS SSPAGAPSPF DKEAEGQFYN YFPN

Target Information

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.