Thermo Fisher Scientific NOTCH3 Monoclonal Antibody (2E2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SPCANGGRCT QLPSREAACL CPPGWVGERC QLEDPCHSGP CAGRGVCQSS VVAGTARFSC RCPRGFRGPD CSLPDPCLSS PCAHGARCSV GPDGRFLCSC PPGYQGRSCR

Target Information

NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 are identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.