Thermo Fisher Scientific NOTCH3 Monoclonal Antibody (2E2)
인간 NOTCH3 단백질을 인식하는 mouse monoclonal antibody. Western blot, ICC/IF, ELISA에 사용 가능. PBS 기반 액상 형태로 제공되며, 보존제 무첨가. -20°C에서 보관, 동결/해동 반복 피해야 함.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E2 |
| Immunogen | NOTCH3 (NP_000426, 47 a.a. approximately 156 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SPCANGGRCT QLPSREAACL CPPGWVGERC QLEDPCHSGP CAGRGVCQSS VVAGTARFSC RCPRGFRGPD CSLPDPCLSS PCAHGARCSV GPDGRFLCSC PPGYQGRSCR
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 are identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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