Thermo Fisher Scientific PD-1 Recombinant Human Monoclonal Antibody (HN94)

Applications

Tested Dilution

Publications

Neutralization (Neu)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG4

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HN94

Immunogen

Recombinant Human PD1/PDCD1/CD279 Protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5.08 mg/mL

Purification

Protein A

Storage buffer

arginine/histidine with 0.02% Tween 80, 120mM NaCl

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912218

Product Specific Information

Specificity: Human PD1/PDCD1/CD279

KD of the antibody is <1.43E-10 M for PD1 (10377-H08H).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of danger signals such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1- mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.