Thermo Fisher Scientific IL-6 Chimeric Recombinant Human Monoclonal Antibody (mhK23)

Applications

Tested Dilution

Publications

Neutralization (Neu)

10 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

mhK23

Immunogen

Recombinant Human IL6/IL-6 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.91 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912220

Product Specific Information

Specificity: Human IL6/IL-6. This product is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The antibody was produced using recombinant antibody technology.

Target Information

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.