Thermo Fisher Scientific PSMA1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
TYLERHMSEF MECNLNELVK HGLRALRETL PAEQDLTTKN VSIGIVGKDL

For short term use, store at 2–8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins, including those involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins, while others are degraded via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome is an ATP-dependent, multisubunit (~31) molecular complex (~2.5 MDa), consisting of a 20S proteolytic core and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and assist in unfolding and translocation into the 20S lumen.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.