Thermo Fisher Scientific ATP11B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ATP11B. Recombinant protein control fragment (Product #RP-96268). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ATP11B,uniProtId:Q9Y2G3-1,ncbiNodeId:9606,antigenRange:427-524,antigenLength:1177,antigenImageFileName:PA5-57578_ATP11B_Q9Y2G3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57578_ATP11B_Q9Y2G3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638349

Product Specific Information

Immunogen sequence: MKYQEINGRL VPEGPTPDSS EGNLSYLSSL SHLNNLSHLT TSSSFRTSPE NETELIKEHD LFFKAVSLCH TVQISNVQTD CTGDGPWQSN LAPSQLEY

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.

Target Information

ATP11B is a widely expressed integral membrane ATPase and is thought to drive the transport of phospholipids across membranes. It has been suggested that ATP11B is hormonally regulated and plays a role in the subnuclear trafficking of transcription factors with RING motifs. While the exact molecule ATP11B transports is unknown, increased mRNA expression of the homologous ATP11A has been observed in cells resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs), suggesting that ATP11B may also play a role in cell survival under harsh conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.