Thermo Fisher Scientific RNF20 Polyclonal Antibody
RNF20 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. Human 및 Chicken 반응성, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific RNF20 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | - |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
| Immunoprecipitation (IP) | Assay-Dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1–100 of Human RNF20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10975724 |
Product Specific Information
- Heat-mediated antigen retrieval recommended prior to tissue staining.
- This antibody is predicted to react with mouse based on sequence homology.
Target Information
RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B.
It selectively suppresses the expression of several proto-oncogenes and growth-related genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Conversely, RNF20 positively regulates the p53 tumor suppressor and numerous histone H2A and H2B genes.
Together with the deubiquitinase USP44, RNF20 modulates stem cell differentiation by regulating H2B monoubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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