Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (TNKUSOHA), eFluor 450, eBioscience

Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (TNKUSOHA), eFluor 450, eBioscience

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 5 µL (0.25 µg)/test

Product Specifications

Additional Formats

• Alexa Fluor™ 700
• APC-eFluor™ 780
• PE-eFluor™ 610
• PerCP-eFluor™ 710
• Request custom conjugation available

Product Specific Information

The TNKUSOHA monoclonal antibody recognizes human CD304, also known as BDCA-4 and Neuropilin-1.
CD304 is expressed on human plasmacytoid dendritic cells in normal blood and bone marrow, and can also be detected on T follicular helper cells in inflamed tonsils, as well as on some B-cell acute lymphoblastic leukemias.
Additionally, CD304 is found on various non-hematopoietic cell types, including neurons, endothelial, and tumor cells.

Plasmacytoid dendritic cells play a key role in the innate immune response against viral pathogens and tumors.
This TNKUSOHA antibody is validated for flow cytometric analysis and can be used at 5 µL (0.25 µg) per test.
A test is defined as the amount of antibody staining a cell sample in a final volume of 100 µL, with cell counts ranging from 10⁵ to 10⁸ cells/test.

eFluor® 450 is an alternative to Pacific Blue®, emitting at 445 nm and excited by the Violet laser (405 nm).
Ensure that your instrument can detect this fluorochrome.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Neuropilin 1 is a 923-amino-acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain.
Neuropilin 1 forms a heterodimer with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
Primarily expressed in the nervous system, Neuropilin 1 is involved in:

• Cardiovascular development
• Angiogenesis
• Axon guidance
• Neuronal circuit formation
• Cell survival and migration
• Organogenesis outside the nervous system

It functions as a receptor for semaphorins and vascular endothelial growth factor (VEGF), regulating VEGF-induced angiogenesis.
Neuropilin 1 is also implicated in aggressive prostate carcinoma and breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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