Thermo Fisher Scientific MCM8 Polyclonal Antibody
MCM8 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 ICC/IF에 적합하며 인간 및 초파리 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Fruit fly |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MCM8. Recombinant protein control fragment (Product #RP-104804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665099 |
Product Specific Information
Immunogen sequence:
ERKGSILVDFK ELTEGGEVTN LIPDIATELR DAPEKTLACM GLAIHQVLTK DLERHAAELQ AQEGLSNDGE TMVNVPHIHA RVYNYEPLTQ LKNVRANYYG KYIALRGTVV RVSNIKPLCT KMAFLCAACG EIQSFPLPDG KYSL
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 87%
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication.
The hexameric complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in replication fork formation and recruitment of other DNA replication-related proteins.
MCM8 contains a central domain conserved among MCM proteins and co-immunoprecipitates with MCM4, 6, and 7, suggesting interactions with other MCM proteins in DNA replication.
Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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