Thermo Fisher Scientific MCM8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

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Product Specifications

Species Reactivity

Human

Published species

Fruit fly

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human MCM8. Recombinant protein control fragment (Product #RP-104804).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2665099

Product Specific Information

Immunogen sequence: ERKGSILVDFK ELTEGGEVTN LIPDIATELR DAPEKTLACM GLAIHQVLTK DLERHAAELQ AQEGLSNDGE TMVNVPHIHA RVYNYEPLTQ LKNVRANYYG KYIALRGTVV RVSNIKPLCT KMAFLCAACG EIQSFPLPDG KYSL

Highest antigen sequence identity to the following orthologs - mouse 88%, rat 87%.

Target Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.