Thermo Fisher Scientific DCX Monoclonal Antibody (OTI4A3), TrueMAB
인간 DCX 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제 제품이며, PBS/BSA/glycerol 완충액에 보관. 신경세포 이동 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A3 |
| Immunogen | Full length human recombinant protein of human DCX produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation.
DCX is a cytoplasmic protein that directs neuronal migration by regulating the organization and stability of microtubules.
It contains two doublecortin domains that bind microtubules and interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase.
This interaction is essential for proper microtubule function in the developing cortex.
Mutations in the DCX gene are known to cause X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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