Thermo Fisher Scientific HIP1 Monoclonal Antibody (13E1)
HIP1 단백질을 인식하는 Thermo Fisher Scientific의 13E1 마우스 단클론 항체. Western blot, IHC, ICC/IF 등에 적합하며 인간 시료에 반응. 높은 특이성과 재현성을 제공하며 암 및 헌팅틴 질환 연구에 활용 가능.
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Thermo Fisher Scientific HIP1 Monoclonal Antibody (13E1)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13E1 |
| Immunogen | Synthetic peptide within Human HIP1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848841 |
Product Specific Information
Positive Control: SH-SY5Y, A549, rat brain tissue, human colon cancer tissue, human prostate cancer tissue, mouse brain tissue.
Target Information
Huntingtin disease, a neurodegenerative disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. It plays a role in clathrin coat recruitment to lipid membranes and may contribute to tumorigenesis by promoting survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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