Thermo Fisher Scientific Phospho-Syk (Tyr525, Tyr526) Monoclonal Antibody (F.724.5)
인간 Syk 단백질의 Tyr525/526 인산화 부위를 인식하는 rabbit monoclonal 항체로, WB, ICC/IF, Flow, IP에 적합. 높은 특이성과 재현성을 제공하며, 다른 인산화된 티로신 키나아제와 교차 반응하지 않음. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 | – |
| Flow Cytometry (Flow) | 1:200–1:800 | – |
| Immunoprecipitation (IP) | 1:50 | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.724.5 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr525/526 of human Syk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 90 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 100 µg/mL BSA |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10989513 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other tyrosine-phosphorylated protein tyrosine kinases.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcεRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its pair of SH2 domains with ITAM motifs of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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