Thermo Fisher Scientific KLC2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

• Ubiquitin C-terminal hydrolases
• Ubiquitin-specific processing proteases (USPs)
• OTU-domain ubiquitin-aldehyde-binding proteins
• Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread and conserved, releasing ubiquitin from conjugated proteins and containing conserved catalytic Cys and His boxes with variable N- or C-terminal extensions for substrate recognition and localization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.