Thermo Fisher Scientific GNAS Monoclonal Antibody (OTI7A6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Mutations in the GNAS gene are associated with several disorders, including pseudohypoparathyroidism type 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and certain pituitary tumors.
This gene exhibits a complex imprinted expression pattern, producing maternally, paternally, and biallelically expressed proteins from alternatively spliced transcripts. The gene structure includes differentially methylated upstream exons, and one transcript variant introduces a frameshift, resulting in a structurally distinct isoform. An antisense transcript may also regulate imprinting in this region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.