Thermo Fisher Scientific Phospho-Neuropilin-1 (Thr916) Polyclonal Antibody
Phospho-Neuropilin-1 (Thr916) 폴리클로날 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 사람 및 소 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경 및 혈관 발달 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -LNTQS- with a phosphorylation site at Thr916 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human brain tissue
- Cellular location: Cytoplasmic, membrane
Target Information
Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family, containing two CUB domains, two F5/8 type C domains, and a MAM domain. It forms a heterodimer with NRP2 and binds to plexin (PLXNB1) to form semaphorin receptors. Expressed mainly in the nervous system, it is involved in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis. Neuropilin 1 also functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis, and is implicated in advanced prostate and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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