Thermo Fisher Scientific CD4 Monoclonal Antibody (74-12-4), FITC

Thermo Fisher Scientific CD4 Monoclonal Antibody (74-12-4), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1 µg/10^6 cells
Publications: -

Product Specifications

Additional Formats

• Unconjugated (MA5-28735)
• APC (MA5-28730)
• Biotin (MA5-28731)
• PE (MA5-28733)
• PE-Cyanine5 (MA5-28734)
• Request custom conjugation available

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is primarily expressed in T helper cells but may also be found in monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression is detectable in thymus, lymph nodes, tonsils, spleen, and specific regions of the brain and gut. CD4 functions to initiate or augment the early phase of T-cell activation through association with the T-cell receptor complex and protein tyrosine kinase Lck. It may also mediate neuronal damage in infectious and immune-mediated diseases of the CNS. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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