Thermo Fisher Scientific VKORC1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human VKORC1, validated for WB, IHC, and ICC/IF. Recognizes recombinant VKORC1 protein with high species homology. Supplied as liquid, unconjugated form at 0.1 mg/mL concentration. Suitable for research use in vitam...
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Published species | Fungi |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human VKORC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649437 |
Product Specific Information
Immunogen sequence:
ARDRDYRALC DVGTAISCSR VFSSRW
Ortholog sequence identity:
- Mouse: 92%
- Rat: 92%
Target Information
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is an enzyme responsible for reducing vitamin K 2,3-epoxide to its active form, essential for blood clotting. The reduced form of vitamin K is required for the carboxylation of glutamic acid residues in certain blood-clotting proteins.
VKORC1 is sensitive to the anticoagulant warfarin. Mutations in VKORC1 are associated with vitamin K–dependent clotting factor deficiencies and warfarin resistance in humans and rats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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