Thermo Fisher Scientific DTYMK Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human DTYMK 단백질을 특이적으로 인식합니다. IHC(P) 및 ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. DNA 합성 및 항암제 연구에 활용됩니다. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DTYMK. Recombinant protein control fragment (Product #RP-98924). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640820 |
Product Specific Information
Immunogen sequence:
RGALIVLEGV DRAGKSTQSR KLVEALCAAG HRAELLRFPE RSTEIGKLLS SYLQKKSDVE DHSVHLLFSA NRWEQVPLIK EKLSQGVTLV VDRYAFSGVA
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 87%
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and serves as an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), a chemotherapeutic drug used for several solid tumors.
The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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