Thermo Fisher Scientific HCoV-229E Spike S1 Polyclonal Antibody
HCoV-229E 스파이크 S1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of coronavirus Spike S1 (NP_073551.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914292 |
Product Specific Information
Positive test controls include Human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECDHis Tag).
Immunogen sequence:
TGRGDCKGFS SDVLSDVIRY NLNFEENLRR GTILFKTSYG VVVFYCTNNT LVSGDAHIPF GTVLGNFYCF VNTTIGNETT SAFVGALPKT VREFVISRTG H
Target Information
The S1 region attaches the virion to the cell membrane by interacting with host ANPEP (aminopeptidase N), initiating infection. Binding to the receptor induces conformational changes in the S glycoprotein, exposing the fusion peptide of the S2 region and activating membrane fusion.
The S2 region belongs to the class I viral fusion proteins and transitions through three conformational states: pre-fusion, pre-hairpin intermediate, and post-fusion hairpin. During membrane fusion, coiled-coil heptad repeats form a trimer-of-hairpins structure, positioning the fusion peptide near the ectodomain C-terminus, driving membrane fusion between virus and host cell.
[Uniprot]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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